Apoptosis is genetically determined process of self-cell destruction of abnormal and damaged cells. If cells of a multicellular organisms are no longer needed, they commit suicide by activating an intracellular death program. It is a natural phenomenon and occurs via a tightly regulated complex signaling cascade. Inhibitor of apoptosis (IAP) protein family members are frequently overexpressed in cancer and contribute to tumor cell survival, chemo-resistance, disease progression, and poor prognosis. Since apoptosis cannot stop once it has begun, it is a highly regulated process. Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die.
Oncology Apoptosis Modulators Market: Drivers and Restraints
Increasing incidence of cancer disease has led to the growth of oncology apoptosis modulators market. Continuous research and development activities undertaken by companies is also driving this market towards growth. Lack of awareness about apoptosis is expected to restrain the growth of oncology apoptosis modulators market.
Oncology Apoptosis Modulators Market: Segmentation
Oncology apoptosis modulators market is segmented based on treatment type and geography.
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Based on treatment type, oncology apoptosis modulators market is segmented as follows:
- Extrinsic pathway
- Intrinsic pathway
- The perforin/granzyme pathway
- Execution pathway
Oncology Apoptosis Modulators Market: Overview
The coagulation cascade of secondary hemostasis has two initial pathways which lead to fibrinformation-intrinsic pathway and extrinsic pathway. Extrinsic pathway play a central role in instructive apoptosis. They are also known as death receptors. Perforin/granzyme-induced apoptosis is the main pathway used by cytotoxic lymphocytes to eliminate virus-infected or transformed cells. In the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis.
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Oncology Apoptosis Modulators Market: Region-wise Outlook
The global oncology apoptosis modulators marketis classified into countries namely, North America, Latin America, Western Europe, Eastern Europe, Asia-Pacific, Japan, Middle East and Africa. North America dominates the oncology apoptosis modulators market because of medical advancement as well as greater awareness about oncology apoptosis modulators followed by Europe. Asia-Pacific is an emerging market due to rising number of newly diagnosed cancer patient population.
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Oncology Apoptosis Modulators Market: Key Players
Some of the major companies contributing to global oncology apoptosis modulators marketare Chroma Therapeutics Ltd, Cancer Research Technology among others.