Albany, New York, December 20, 2016: A latest report by Global Market Direct has been added to the broad database of Market Research Hub, titled “Protein Kinase C Epsilon Type – Pipeline Review, H2 2016”. It delivers comprehensive information on the Protein Kinase C Epsilon Type (nPKC Epsilon or PRKCE or EC 220.127.116.11) targeted therapeutics with analysis by indications, stage of development, mechanism of action (MoA), and molecule type. It also reviews key players involved in Protein Kinase C Epsilon Type targeted therapeutics development, features inactive and discontinued projects along with latest news & press releases from company/university websites and industry specific third party sources.
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The report studies that, PKCs are important components of intracellular signal transduction pathways and have been occupied in regulating a wide variety of biological functions ranging from cell growth, differentiation and apoptosis to synaptic plasticity and from neuronal injury to cellular immune responses. Protein Kinase C Epsilon Type also known as nPKC-Epsilon or EC 18.104.22.168, is an enzyme belonging to a family of serine and threonine-specific protein kinases i.e. activated by calcium as well as the second messenger diacylglycerol. This kinase displayed involvement in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response as well as insulin exocytosis.
Also, the Protein Kinase C Epsilon Type market can be segmented by therapy, by route of administration and drug class. In the terms of therapy, it is classified into monotherapy & combination therapy. The combination therapy offers a wide therapeutic range, thus the segment is showing high acceptance. The report also covers pipeline products which are based on various stages of development ranging from pre-registration till discovery and undisclosed stages.
Protein Kinase C Epsilon Type (nPKC-Epsilon or EC 22.214.171.124) pipeline target constitutes close to 8 molecules. Out of which almost 8 molecules are developed by companies. Companies involved in the therapeutics development mentioned in the report are:
- Hadasit Medical Research Services & Development Ltd.
- VM Discovery, Inc.
Moreover, the report also highlights investigational drugs from across the world covering over 20 therapy areas and nearly 3,000 indications. Some of the drug profiles included in the report are DHACP-6, VMD-1201, VMD-2202, Bryostatin-1 and small molecule to activate Epsilon PKC for traumatic brain injury, ischemic stroke, neurology, type 2 diabetes and insulin resistance. According to a featured news and press release in 2016, Bryostatin (a PKC epsilon activator) produces new synapses through accumulation of the synaptic anchoring protein PSD-95 at neuronal membranes.
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